Levo medetomidine hydrochloride. In human medicine, medetomidine is most similar to dexmedetomidine and clonidine. Medetomidine is a synthetic alpha-2 adrenoreceptor agonist sedative used in veterinary medicine. MEDETOMIDINE RAPIDLY PROLIFERATING ACROSS USA — IMPLICATED IN RECREATIONAL OPIOID DRUG SUPPLY & CAUSING OVERDOSE OUTBREAKS PURPOSE: The objective of this announcement is to notify public health, harm reduction, first responders, clinicians, medical examiners and coroners, forensic and clinical laboratories, and all other related communities about new information surrounding the emergent May 22, 2024 · The "iron law of prohibition" is alive and well. Effects can be reversed using atipamezole. 190000-46-5, Synonyms: Medetomidine (R)-Isomer, Chemical name: (R)-5- (1- (2,3-dimethylphenyl)ethyl)-1H-imidazole hydrochloride. For research use only. Buy high-quality Levomedetomidine Hydrochloride from SynZeal. Just what we don't need: another adulterant in an already-deadly street drug. S. Purity: ≥98%. In veterinary literature, the effects of medetomidine include sedation, analgesia, muscle relaxation and anxiolysis (i. Synonym: (R)-Medetomidine. states and Canada. We do not sell to patients. May 1, 2025 · Medetomidine, an alpha-2 adrenoreceptor agonist that is not approved for human use in the United States, became increasingly detected in the drug supply in 2024. Levomedetomidine (hydrochloride): The levorotary enantiomer of medetomidine. Sep 18, 2025 · Medetomidine, a non-opioid drug used in veterinary medicine, is being added to Philadelphia's street drug supply. Levomedetomidine hydrochloride is an isomer of Medetomidine (HY-17034), and a cardioprotectiv e agent with sedative and analgesic effects. Below are recommendations for adapting overdose responses to address prolonged sedation from medetomidine, and tips for triaging patients with medetomidine withdrawal syndrome in behavioral health settings. Medetomidine is a veterinary anesthetic medication with potent sedative effects and emerging illicit drug adulterant. The alpha 2 receptor therefore generally . Levomedetomidine Hydrochloride Reference Standard is supplied with COA and analytical data. An animal anesthetic related to – but worse than – xylazine (Tranq) is called medetomidine. Since 2022, medetomidine has been found as an adulterant in samples of seized drugs, as well as in toxicological analyses of patients admitted to the emergency department after suspected overdoses across several U. Although similar to xylazine, medetomidine is 100-200 times more potent and can cause longer-lasting effects, as well as more severe withdrawal symptoms. When activated, the alpha 2 receptor decreases release of norepinephrine from the presynaptic neuron. It's starting to be detected in samples of illicit fentanyl. And it's all predictable. The alpha 2 receptor is responsible for negative feedback of norepinephrine release. Feb 2, 2025 · Pharmacology Medetomidine is an alpha 2 adrenergic receptor agonist like xylazine (another veterinary medication found in the opioid supply), clonidine, and guanfacine. Levomedetomidine hydrochloride | C13H17ClN2 | CID 123602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. [4] It is a racemic mixture of two stereoisomers, levomedetomidine and dexmedetomidine, the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist. It is not approved for use in humans. e. CAS Number: 190000-46-5. Medetomidine is a racemic mixture of levomedetomidine and dexmedetomidine, an intravenous sedative used in the critical care setting. CAS No. , anti-anxiety). Medetomidine is more potent than xylazine May 29, 2024 · Medetomidine, a chemical long used by veterinarians and doctors, is now turning up in the street drug supply and triggering a new wave of overdoses. 9bx beee nnovqc bv iuy7 rebd xzn c01pa qxxu3l gfslmb